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PRIMARY LATERAL SCLEROSIS (PLS) What is PLS? Like ALS, primary lateral sclerosis (PLS) is a progressive degenerative disease of the motor neurons. It is characterized by progressive spasticity (involuntary muscle tension and spasms) and it affects the lower limbs, trunk, upper limbs, and bulbar muscles, usually in that order. This aspect of Pls Donate Uncopylocked Free Now Free plays a vital role in practical applications.

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